反应详情

温度

80 °C

To a solution of 2 g (7.75 mmole) of S-(2-aminostyryl)-S-phenyl sulfoximine in 20 ml of dimethylformamide was added 1 g (8.5 mmole) of dimethylformamide dimethyl acetal and the mixture was heated at 80° C. for 15 minutes. The mixture was then cooled and diluted with 100 ml of ethyl acetate. The organic phase was washed 3 times with 75 ml of water, dried over magnesium sulfate and evaporated to an oil which was crystallized from ether/petrol to obtain 1.67 g (80%) of 1,5-diphenyl-1H-1,2,4-thiadiazine-1-oxide melting at 110°-111° C.

1. temperatureThe mixture was then cooled
2. washThe organic phase was washed 3 times with 75 ml of water
3. dry with materialdried over magnesium sulfate
4. customevaporated to an oil which
5. customwas crystallized from ether/petrol