Hydrochloric Acid → HCID 13453787, compound

HRID 1906832Notes

Reaction equation

HRID 1906832 reaction equation
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][S:11][C:12]1[N:13]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:14]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:16]=1.[H-].[Na+].CO.Cl>O1CCCC1.O>[C:29]1([N:13]2[C:14]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:15]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:16]=[C:12]2[S:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:35])=[O:2])[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 24758Sodium hydrideHCID 54312872Methyl 8-[(1,4,5-triphenyl-1H-imidazol-2-yl)sulfanyl]octanoate

Product 1

HCID 13453787HCID 13453787, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

170 g of 8-(1.4.5-triphenylimidazol-2-yl mercapto)-octanoic acid methyl ester are dissolved in 1.2 l of tetrahydrofurane. 42 g of sodium hydride dissolved in 700 cc. of methanol are added thereto. The mixture is stirred 24 hours at 40° to 50° C., cooled, diluted with about 2 l of water and acidified with delute hydrochloric acid. The crude acid is filtered off, dried and recrystallized from toluene.

Workup

  1. temperaturecooled
  2. filtrationThe crude acid is filtered off
  3. customdried
  4. customrecrystallized from toluene

Sources & evidence

ORD record
ord-4cefeb0dc46b4426a1a9f5f5700ea78a
Source dataset
uspto-grants-1987_03
Patent number
US04654358

Reaction notes

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