反应详情

温度

160 °C

The TFA salt of (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one (6 mg, 0.018 mmol), 6-chloroimidazo[1,2-b]pyridazine (6 mg, 2.15 equiv.), and i-Pr2NEt (30 μL, excess) were mixed with isopropanol (1 mL). The mixture was heated in a microwave oven at 160° C. for 2.5 h. After being cooled to rt, the mixture was filtered and purified by prep HPLC to afford the title compound (0.82 mg) as brown oil. LC-MS Method 1 tR=1.07 min., m/z=450 (M+1).

1. temperatureAfter being cooled to rt
2. filtrationthe mixture was filtered
3. custompurified by prep HPLC