Hydrochloric Acid → HCID 66624139, compound

HRID 1907353Notes

Reaction equation

HRID 1907353 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[C:21]([CH2:24][OH:25])[S:22][CH:23]=4)=[CH:15][N:14]3[CH:26]=2)[CH:2]=1.[ClH:27]>ClCCl.CO.C(O)(C)C>[ClH:27].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[C:21]([CH2:24][OH:25])[S:22][CH:23]=4)=[CH:15][N:14]3[CH:26]=2)[CH:2]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 44234055HCID 44234055, compound

Product 1

HCID 66624139HCID 66624139, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

Workup

  1. additionare added to the filtrate
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. filtrationThe precipitate is recovered by filtration
  4. customoven-dried under reduced pressure

Sources & evidence

ORD record
ord-3499dcdd857b4a04928ce9a20182cd63
Source dataset
uspto-grants-2013_12
Patent number
US08598166B2

Reaction notes

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