Hydrochloric Acid → Tert-butyl 4,4-difluoro-2-[4-(5-fluoropyridin-2-yl)benzyl]-2-{[(2-hydroxy-4,4-dimethylhexyl)amino]carbonyl}pyrrolidine-1-carboxylate
Reaction equation
[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[N:15]1[C:16]([C:17](=[O:18])[OH:19])([CH2:25][c:26]2[cH:27][cH:28][c:29](-[c:32]3[n:33][cH:34][c:35]([F:38])[cH:36][cH:37]3)[cH:30][cH:31]2)[CH2:20][C:21]([F:23])([F:24])[CH2:22]1.[CH3:1][N:2]1[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1.[CH3:50][N:51]([CH3:52])[CH2:53][CH2:54][CH2:55][N:56]=[C:57]=[N:58][CH2:59][CH3:60].[Cl:71][CH2:72][Cl:73].[ClH:49].[NH2:39][CH2:40][CH:41]([CH2:42][C:43]([CH2:44][CH3:45])([CH3:46])[CH3:47])[OH:48].[OH:61][c:62]1[c:63]2[n:64][n:65][nH:66][c:67]2[cH:68][cH:69][cH:70]1>>[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[N:15]1[C:16]([C:17](=[O:19])[NH:39][CH2:40][CH:41]([CH2:42][C:43]([CH2:44][CH3:45])([CH3:46])[CH3:47])[OH:48])([CH2:25][c:26]2[cH:27][cH:28][c:29](-[c:32]3[n:33][cH:34][c:35]([F:38])[cH:36][cH:37]3)[cH:30][cH:31]2)[CH2:20][C:21]([F:23])([F:24])[CH2:22]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-f3c75068553742fd8813cb4888794712
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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