Hydrochloric Acid → 1-(3-Hydroxypyridin-2-yl)ethan-1-one

Temperature

60 °C

A solution of MeMgBr (390 mL of 1.4 M in toluene/THF (75:25), 540 mmol) was heated at 60° C. and a solution of 3-hydroxypyridine-2-carboxylic acid (15 g, 110 mmol) and triethylamine (15 mL, 110 mmol) in THF (75 mL) was added dropwise over 3 hours. The resulting mixture was then stirred for 2 hours at 60° C. The reaction mixture was cooled on an ice/brine bath and methyl formate (13 mL, 220 mmol) was added keeping the internal temperature below 20° C. The reaction mixture was then acidified to pH 5-6 with 1M aqueous HCl, and the layers were separated, and the aqueous layer was extracted with ethyl acetate (3×). The organic phases were combined, washed with brine, dried over sodium sulfate and evaporated to dryness to afford 1-(3-hydroxypyridin-2-yl)ethanone (4.0 g, 27%). ESI-MS m/z calc. 137.1. found 138.3 (M+1)+; Retention time: 0.62 minutes (3 min run).

1. temperatureThe reaction mixture was cooled on an ice/brine bath
2. customthe internal temperature below 20° C
3. customthe layers were separated
4. extractionthe aqueous layer was extracted with ethyl acetate (3×)
5. washwashed with brine
6. dry with materialdried over sodium sulfate
7. customevaporated to dryness

ORD record

ord-c365e40d501f4c1b8fd8233ace191c20

Source dataset

uspto-grants-2013_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08598164B2