Hydrochloric Acid → HCID 68536828, compound

HRID 1910402Notes

Reaction equation

HRID 1910402 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]1([CH2:18][O:19][CH3:20])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1.[ClH:21]>CCOC(C)=O>[ClH:21].[CH3:1][O:2][CH2:3][CH2:4][C:5]1([CH2:18][O:19][CH3:20])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68532329HCID 68532329, compound

Product 1

HCID 68536828HCID 68536828, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl 4-(2-methoxyethyl)-4-(methoxymethyl)piperidine-1-carboxylate (400 mg) in EtOAc (7 ml) was added 1 N HCl (7 ml) under ice bath cooling, and the mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated in vacuo to give 4-(2-methoxyethyl)-4-(methoxymethyl)piperidine hydrochloride (260 mg) as a white powder. The obtained crude product was used in next reaction without further purification.

Workup

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-23c44ee005ad460db0340ab9965ce3d3
Source dataset
uspto-grants-2013_12
Patent number
US08603975B2

Reaction notes

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