2-Amino-2-methyl-1-propanol → HCID 8626742, compound

HRID 1910787Notes

Reaction equation

HRID 1910787 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[C:11]=[S:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:13][C:14]([CH3:18])([CH3:17])[CH2:15][OH:16]>C1COCC1>[OH:16][CH2:15][C:14]([NH:13][C:11]([NH:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)=[S:12])([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 75044Benzene, 1-isothiocyanato-4-nitro-

Product 1

HCID 8626742HCID 8626742, compoundYield 66.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-nitro-phenyl-isothiocyanate (4 g, 22.2 mmol) and 2-amino-2-methyl-propan-1-ol (1.9 g, 21.3 mmol) in THF was stirred overnight at r.t. The solvent was evaporated to give a residue which was triturated with ether to give 1-(2-hydroxy-1,1-dimethyl-ethyl)-3-(4-nitro-phenyl)-thiourea (3.8 g, 66%).

Workup

  1. customThe solvent was evaporated
  2. customto give a residue which
  3. customwas triturated with ether

Sources & evidence

ORD record
ord-28cffd716a724f7680cf3e7ca6ce0b80
Source dataset
uspto-grants-2013_12
Patent number
US08604029B2

Reaction notes

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