Toluene → 3-formyl-N-methylbenzamide

Temperature

-50 °C

A 2M solution of methylamine in THF (44 mL, 5 eq, 87.5 mmol) was added to methyl 3-formylbenzoate (2.875 g, 1 eq, 17.5 mmol) in dry THF (65 ml). The reaction mixture was cooled to −50° C. under nitrogen and a 2M solution of trimethylaluminium in toluene (22 ml, 2.5 eq, 43.75 mmol) was added slowly over 15 mins. The reaction mixture was allowed to warm slowly to room temperature and stirred for 18 h. The reaction mixture was quenched with a 20% w/v solution of potassium sodium tartrate in water (50 ml). This was extracted with ethyl acetate (2×100 ml) and washed with water (50 ml), saturated sodium chloride solution (50 ml), dried over MgSO4 and evaporated under reduced pressure to give a gum. The crude product was purified by silica column chromatography, eluting with a gradient of 0 to 2.5% methanol in DCM. Pure fractions were combined and evaporated to afford 3-formyl-N-methylbenzamide (1.6502 g, 58%) as an off-white solid.

1. temperatureto warm slowly to room temperature
2. customThe reaction mixture was quenched with a 20% w/v solution of potassium sodium tartrate in water (50 ml)
3. extractionThis was extracted with ethyl acetate (2×100 ml)
4. washwashed with water (50 ml), saturated sodium chloride solution (50 ml)
5. dry with materialdried over MgSO4
6. customevaporated under reduced pressure
7. customto give a gum
8. customThe crude product was purified by silica column chromatography
9. washeluting with a gradient of 0 to 2.5% methanol in DCM
10. customevaporated

ORD record

ord-951620bcdad2477a8f541a9e7020a327

Source dataset

uspto-grants-2013_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08604022B2