反应详情

To a stirred mixture of (R)-2-amino-3-phenylsulfanyl-propan-1-ol (0.09 g, 0.49 mmol) and K2CO3 (0.081 g, 0.59 mmol) in THF (3 ml) under an argon atmosphere was added a solution of cyanogen bromide (0.062 g, 0.59 mmol) in THF (1 ml). The mixture was stirred overnight, then ethyl acetate and water were added. The aqueous phase was back-extracted with EtOAc. The combined organics were dried over MgSO4, filtered and concentrated. The crude product was purified by column chromatography (column: Isolute® Flash-NH2 from Separtis; eluent: EtOAc/MeOH=95:5) to yield a light yellow solid, (0.026 g, 26%); MS (ISP): 209.1 ((M+H)+.).

1. extractionThe aqueous phase was back-extracted with EtOAc
2. dry with materialThe combined organics were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated
5. customThe crude product was purified by column chromatography (column: Isolute® Flash-NH2 from Separtis; eluent: EtOAc/MeOH=95:5)
6. customto yield a light yellow solid, (0.026 g, 26%)