反应详情

Potassium carbonate (0.62 g, 4.5 mmol) was added to a solution of 2-chloro-8-methyl-quinoline-3-carbaldehyde (0.45 g, 2.2 mmol) and cyclobutylmethyl-ethyl-amine (0.47 g, 4.1 mmol) in anhydrous dimethyl formamide (5 mL) under nitrogen. After stirring for 0.5 h at RT, the reaction mixture was heated for 20 h at 80-95° C. Thereafter, the reaction was cooled to RT, water (30 mL) and ethyl acetate (30 mL) were added, and the organic layer was separated from the aqueous mixture. The organic extract was washed with brine, dried over sodium sulfate and the solvent was evaporated in vacuo. The residue was purified by chromatography using silica gel to afford the title compound as a pale yellow liquid (0.46 g, 75%).

1. temperaturethe reaction mixture was heated for 20 h at 80-95° C
2. temperatureThereafter, the reaction was cooled to RT
3. customthe organic layer was separated from the aqueous mixture
4. extractionThe organic extract
5. washwas washed with brine
6. dry with materialdried over sodium sulfate
7. customthe solvent was evaporated in vacuo
8. customThe residue was purified by chromatography