Hydrochloric Acid → HCID 178503294, compound

HRID 1913497Notes

Reaction equation

HRID 1913497 reaction equation
[CH3:1][S:2][C:3](SC)=[C:4]([C:7]#[N:8])[C:5]#[N:6].[C:11]([CH2:13][C:14]([NH2:16])=[S:15])#[N:12].C(N(CC)CC)C.Cl>CN(C=O)C>[NH2:8][C:7]1[C:4]([C:5]#[N:6])=[C:3]([S:2][CH3:1])[C:13]([C:11]#[N:12])=[C:14]([SH:15])[N:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrileHCID 14162772-Cyanoethanethioamide

Product 1

HCID 178503294HCID 178503294, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

10 g (58.74 mmol) of 2-(di(methylthio))methylidenemalononitrile and 7.1 g (70.48 mmol) of cyanothioacetamide were initially charged in 21 ml of DMF, and 16.4 ml (117.47 mmol) of triethylamine were added dropwise at room temperature. The mixture was stirred at room temperature for 8 h. The reaction mixture was added to 300 ml of 3N hydrochloric acid. The resulting precipitate was filtered off with suction, washed with water and dried. This gave the product as a powder.

Workup

  1. filtrationThe resulting precipitate was filtered off with suction
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-e9140ad50a22404b94914cac713dc37a
Source dataset
uspto-grants-2013_12
Patent number
US08609686B2

Reaction notes

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