Dimethylformamide → 4'-Methyl-2-nitro-1,1'-biphenyl

HRID 1914403Notes

Reaction equation

HRID 1914403 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH3:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].CN(C)C=O>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O>[CH3:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])=[CH:14][CH:13]=1

Participants

8

Reactant 4

HCID 6228DimethylformamideHCID 113411-Bromo-2-nitrobenzeneHCID 62657Potassium Phosphate, TribasicHCID 79799Tolylboronic acid

Product 1

HCID 104431944'-Methyl-2-nitro-1,1'-biphenylYield 81.5%

Reagents, catalysts & solvents 3

HCID 74236Tetrabutylammonium BromideCatalystHCID 167845palladium(II) acetateCatalystHCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixed solution of 10 g of 2-bromonitrobenzene, 8.2 g of 4-methylphenylboronic acid, 25.4 g of tripotassium phosphate, 3.9 g of tetrabutylammonium bromide, 270 mg of palladium acetate and 150 ml of dimethylformamide was heated and stirred under a nitrogen gas stream at 130° C. for 3 hours. The solution was cooled to room temperature and 100 ml of water was poured into the solution, followed by extraction with 150 ml of ethyl acetate. The organic layer was washed twice with 100 ml of water, dried over magnesium sulfate and then evaporated. The concentrate was purified by silica gel column chromatography and then vacuum-dried to obtain 8.6 g of 2-(4-methylphenyl)nitrobenzene.

Workup

  1. temperatureThe solution was cooled to room temperature
  2. extractionfollowed by extraction with 150 ml of ethyl acetate
  3. washThe organic layer was washed twice with 100 ml of water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customThe concentrate was purified by silica gel column chromatography
  7. customvacuum-dried

Sources & evidence

ORD record
ord-b65ad1b26c404272befc9ab2a9d3344b
Source dataset
uspto-grants-2013_12
Patent number
US08610345B2

Reaction notes

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