反应详情

3-(2-Chloropyridin-4-yloxy)-4-fluorobenzoic acid methyl ester (2.81 g, 10.0 mmol) was dissolved in tetrahydrofuran (15 mL) and mixed with 2M lithium hydroxide (15 mL, 30 mmol). The suspension was stirred for 5 h. To the reaction was added water, then extracted with EtOAc. The aqueous layer was treated with 6M HCl (5 mL, 30 mmol) and then extracted with EtOAc (3×25 mL). The extract was dried (MgSO4), filtered and evaporated to 3-(2-Chloropyridin-4-yloxy)-4-fluorobenzoic acid. Yield: 2.22 g, 83%.

1. extractionextracted with EtOAc
2. extractionextracted with EtOAc (3×25 mL)
3. dry with materialThe extract was dried (MgSO4)
4. filtrationfiltered
5. customevaporated to 3-(2-Chloropyridin-4-yloxy)-4-fluorobenzoic acid