Sodium Thiosulfate → 4,6-Dichloro-2-(methylsulfonyl)pyrimidine

A solution of 4,6-dichloro-2-(methylthio)pyrimidine (48.3 g, 247 mmol) in dichloromethane (1 L) was cooled on an ice bath. 3-Chloroperoxybenzoic acid (152 g, 619 mmol) was added portion-wise keeping the temperature below 10° C. The solution was allowed to warm to room-temperature and stirred over-night. The mixture was diluted with dichloromethane (2 L) and treated with an aqueous solution of sodium thiosulphate and sodium hydrogen carbonate (600 mL). The resulting mixture was stirred over-night. The phases were separated and the organic layer was washed with sodium hydrogencarbonate (500 mL) and brine (1 L), dried over sodium sulphate, filtrated and concentrated in vacuo. The resulting yellow solid was stirred with ether and 4,6-dichloro-2-methanesulfonyl-pyrimidine (32.6 g, 58%) was collected by filtration as a white solid.

1. customthe temperature below 10° C
2. temperatureto warm to room-temperature
3. stirringThe resulting mixture was stirred over-night
4. customThe phases were separated
5. washthe organic layer was washed with sodium hydrogencarbonate (500 mL) and brine (1 L)
6. dry with materialdried over sodium sulphate
7. filtrationfiltrated
8. concentrationconcentrated in vacuo
9. stirringThe resulting yellow solid was stirred with ether and 4,6-dichloro-2-methanesulfonyl-pyrimidine (32.6 g, 58%)
10. filtrationwas collected by filtration as a white solid

ORD record

ord-f5a5ccb58ec8449ea05ed040f894b3f0

Source dataset

uspto-grants-2013_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08618099B2