Triethylamine → HCID 59447944, compound

HRID 1916304Notes

Reaction equation

HRID 1916304 reaction equation
[N:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][N:8]=[CH:9][CH:10]=3)[C:5]=2[C:4](O)=[N:3][CH:2]=1.C(N(CC)CC)C.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][C:4]1[C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[N:8][CH:7]=3)[NH:12][C:13]=2[N:1]=[CH:2][N:3]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 24813Phosphorus oxychlorideHCID 178518049HCID 178518049, compound

Product 1

HCID 59447944HCID 59447944, compound

Procedure

A suspension of 9H-1,3,6,9-Tetraaza-fluoren-4-ol (330 mg) and 500 μL of triethylamine were stirred vigorously overnight at 100° C. in 10 mL phosphorous oxychloride. The reaction mixture was then concentrated in vacuo and a small amount of the title compound was isolated by triturating the residue with water. The filtrate was concentrated in vacuo to give 363 mg of title compound which was used without further purification. LCMS (1): Rt 1.11 min; m/z 205 [M+H]+.

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-af1d4674c6104570bff3e829520451dc
Source dataset
uspto-grants-2013_12
Patent number
US08618121B2

Reaction notes

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