Piperidine → Ethyl 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-3-methyl-1-(2-pyrrolidin-1-yl-ethyl)-1h-indole-2-carboxylate

HRID 1916739Notes

Reaction equation

HRID 1916739 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[C:7]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:6]2[CH3:24])#[CH:2].[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:33]=[CH:34][C:35](I)=[N:36][CH:37]=2)=[CH:28][CH:27]=1.N1CCCCC1>C1COCC1.O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I>[Cl:25][C:26]1[CH:27]=[CH:28][C:29]([C:32]2[CH:33]=[CH:34][C:35]([C:2]#[C:1][C:3]3[CH:4]=[C:5]4[C:9](=[CH:10][CH:11]=3)[N:8]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH2:17][CH2:18]3)[C:7]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:6]4[CH3:24])=[N:36][CH:37]=2)=[CH:30][CH:31]=1

Participants

8

Reactant 3

HCID 8082PiperidineHCID 859698495-(4-Chlorophenyl)-2-iodopyridineHCID 86594685ethyl 5-ethynyl-3-methyl-1-(2-pyrrolidin-1-yl-ethyl)-1H-indole-2-carboxylate

Product 1

HCID 59835807Ethyl 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-3-methyl-1-(2-pyrrolidin-1-yl-ethyl)-1h-indole-2-carboxylate

Reagents, catalysts & solvents 4

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 178418476HCID 178418476, compoundCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Under an argon atmosphere 11 mg (0.02 mmol) Pd(PPh3)2Cl2 and 3 mg (0.02 mmol) CuI are added to a solution of 250 mg (0.77 mmol) ethyl 5-ethynyl-3-methyl-1-(2-pyrrolidin-1-yl-ethyl)-1H-indole-2-carboxylate and 243 mg (0.77 mmol) 5-(4-chloro-phenyl)-2-iodo-pyridine in 1.52 mL (15.4 mmol) piperidine and 25 mL THF and the reaction mixture is stirred for 4 h at RT. It is diluted with water, extracted exhaustively with EtOAc, the combined organic phases are washed with water and saturated NaCl solution and dried over Na2SO4. After the desiccant and solvent have been eliminated the residue is purified first by chromatography (silica gel, cyc/EtOAc 2:1) and then by HPLC.

Workup

  1. extractionextracted exhaustively with EtOAc
  2. washthe combined organic phases are washed with water and saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customis purified first by chromatography (silica gel, cyc/EtOAc 2:1)

Sources & evidence

ORD record
ord-1125257b5b994b22879578fb6a67031a
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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