反应详情

0.81 mL (9.9 mmol) pyrrolidine are added to a suspension of 2.37 g (9.0 mmol) N-(5-bromo-3-methyl-pyridin-2-yl)-2-chloro-acetamide and 2.49 g (18 mmol) K2CO3 in 22.5 mL DMF and the reaction mixture is stirred for 20 h at RT. It is diluted with water, extracted exhaustively with EtOAc, the combined organic phases are washed with water and dried over Na2SO4. After the desiccant and solvent have been eliminated the residue is taken up in a little diisopropylether, cooled to 0° C., the crystals precipitated are suction filtered and dried in the air.

1. extractionextracted exhaustively with EtOAc
2. washthe combined organic phases are washed with water
3. dry with materialdried over Na2SO4
4. temperaturecooled to 0° C.
5. customthe crystals precipitated
6. filtrationare suction filtered
7. customdried in the air