反应详情

温度

110 °C

690 mg of 3-Amino-4-trifluoromethyl-benzoic acid methyl ester, 650 mg of K2CO3, 30 mg of CuI, and 28 mg of N,N′-dimethylethylendiamine were suspended using 4.1 ml of anhydrous toluene. 410 mg of o-bromo-(2-bromo)vinylbenzene were added and the reaction mixture stirred at 110° C. for 14 h. The reaction mixture was allowed to cool to room temperature, 50 ml of EA added, filtrated, and evaporated. Chromatography on silica gel using EA/HEP (gradient) yielded 220 mg of the title compound, viscous oil.

1. temperatureto cool to room temperature
2. filtrationfiltrated
3. customevaporated