HRID1920607

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID311

Citric acid

C6H8O7

4 次

HCID65432

1,4-Dioxane-2,5-dione

C4H4O4

结构：C[C@H](N)C(=O)N[C@@H](CC1C=NC=N1)C(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](N)Cc1ccc2ccccc2c1

HCID5487480

未命名化合物

4 次

PRODUCTS

生成物

结构：CN1CCCC1=O.C[C@H](N)C(=O)N[C@@H](CC1C=NC=N1)C(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](N)Cc1ccc2ccccc2c1.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]

HCID131729695

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

The following composition was prepared. The polymer solution was composed of 50% by weight of poly(lactide-co-glycolide) (PLGH) with a lactide to glycolide ratio of 75/25 and with an inherent viscosity of 0.20 dL/g dissolved in 50% by weight N-methyl-2-pyrrolidone. The active portion was composed of GHRP-1 and citric acid. The ratio of citric acid to GHRP-1 was about 1.25:1 on a molar basis. The GHRP-1 was dissolved in water; citric acid was added to dissolve; and the solution was filled into a syringe and lyophilized. The contents of the completed syringe were about 80 mg of GHRP-1 and about 20 mg of citric acid.

WORKUP

后处理

customThe following composition was prepared
dissolutionto dissolve
additionand the solution was filled into a syringe

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-022caf25e136418bbb516df466b19be9
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08173148B2
来源说明: uspto-grants-2012_05

反应 SMILES

C1[O:8][C:6](=O)[CH2:5]OC1=O.[CH3:9][C@H:10]([NH2:78])[C:11]([NH:13][C@H:14]([C:21]([NH:23][C:24]([C@@H:26]([NH:32][C:33]([C@H:35]([NH:43][C:44]([C@@H:46]([NH:57][C:58]([C@@H:60]([NH:62][C:63]([C@H:65]([NH2:77])[CH2:66][C:67]1[CH:76]=[CH:75][C:74]2[C:69](=[CH:70][CH:71]=[CH:72][CH:73]=2)[CH:68]=1)=[O:64])[CH3:61])=[O:59])[CH2:47][C:48]1[C:56]2[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=2)[NH:50][CH:49]=1)=[O:45])[CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])[CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])=[O:25])=[O:22])[CH2:15][CH:16]1[N:20]=[CH:19][N:18]=[CH:17]1)=[O:12].[C:79]([OH:91])(=[O:90])[CH2:80][C:81]([CH2:86][C:87]([OH:89])=[O:88])([C:83]([OH:85])=[O:84])[OH:82]>CN1CCCC1=O.O>[CH3:14][N:13]1[C:6](=[O:8])[CH2:5][CH2:10][CH2:11]1.[CH3:9][C@H:10]([NH2:78])[C:11]([NH:13][C@H:14]([C:21]([NH:23][C:24]([C@@H:26]([NH:32][C:33]([C@H:35]([NH:43][C:44]([C@@H:46]([NH:57][C:58]([C@@H:60]([NH:62][C:63]([C@H:65]([NH2:77])[CH2:66][C:67]1[CH:76]=[CH:75][C:74]2[C:69](=[CH:70][CH:71]=[CH:72][CH:73]=2)[CH:68]=1)=[O:64])[CH3:61])=[O:59])[CH2:47][C:48]1[C:56]2[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=2)[NH:50][CH:49]=1)=[O:45])[CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])=[O:25])=[O:22])[CH2:15][CH:16]1[N:20]=[CH:19][N:18]=[CH:17]1)=[O:12].[C:79]([O-:91])(=[O:90])[CH2:80][C:81]([CH2:86][C:87]([O-:89])=[O:88])([C:83]([O-:85])=[O:84])[OH:82]