Citric Acid → HCID 131729695, compound

HRID 1920607Notes

Reaction equation

HRID 1920607 reaction equation
C1[O:8][C:6](=O)[CH2:5]OC1=O.[CH3:9][C@H:10]([NH2:78])[C:11]([NH:13][C@H:14]([C:21]([NH:23][C:24]([C@@H:26]([NH:32][C:33]([C@H:35]([NH:43][C:44]([C@@H:46]([NH:57][C:58]([C@@H:60]([NH:62][C:63]([C@H:65]([NH2:77])[CH2:66][C:67]1[CH:76]=[CH:75][C:74]2[C:69](=[CH:70][CH:71]=[CH:72][CH:73]=2)[CH:68]=1)=[O:64])[CH3:61])=[O:59])[CH2:47][C:48]1[C:56]2[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=2)[NH:50][CH:49]=1)=[O:45])[CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])[CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])=[O:25])=[O:22])[CH2:15][CH:16]1[N:20]=[CH:19][N:18]=[CH:17]1)=[O:12].[C:79]([OH:91])(=[O:90])[CH2:80][C:81]([CH2:86][C:87]([OH:89])=[O:88])([C:83]([OH:85])=[O:84])[OH:82]>CN1CCCC1=O.O>[CH3:14][N:13]1[C:6](=[O:8])[CH2:5][CH2:10][CH2:11]1.[CH3:9][C@H:10]([NH2:78])[C:11]([NH:13][C@H:14]([C:21]([NH:23][C:24]([C@@H:26]([NH:32][C:33]([C@H:35]([NH:43][C:44]([C@@H:46]([NH:57][C:58]([C@@H:60]([NH:62][C:63]([C@H:65]([NH2:77])[CH2:66][C:67]1[CH:76]=[CH:75][C:74]2[C:69](=[CH:70][CH:71]=[CH:72][CH:73]=2)[CH:68]=1)=[O:64])[CH3:61])=[O:59])[CH2:47][C:48]1[C:56]2[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=2)[NH:50][CH:49]=1)=[O:45])[CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])=[O:25])=[O:22])[CH2:15][CH:16]1[N:20]=[CH:19][N:18]=[CH:17]1)=[O:12].[C:79]([O-:91])(=[O:90])[CH2:80][C:81]([CH2:86][C:87]([O-:89])=[O:88])([C:83]([O-:85])=[O:84])[OH:82]

Participants

6

Reactant 3

HCID 311Citric Acid4×HCID 65432GlycolideHCID 5487480HCID 5487480, compound4×

Product 1

HCID 131729695HCID 131729695, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The following composition was prepared. The polymer solution was composed of 50% by weight of poly(lactide-co-glycolide) (PLGH) with a lactide to glycolide ratio of 75/25 and with an inherent viscosity of 0.20 dL/g dissolved in 50% by weight N-methyl-2-pyrrolidone. The active portion was composed of GHRP-1 and citric acid. The ratio of citric acid to GHRP-1 was about 1.25:1 on a molar basis. The GHRP-1 was dissolved in water; citric acid was added to dissolve; and the solution was filled into a syringe and lyophilized. The contents of the completed syringe were about 80 mg of GHRP-1 and about 20 mg of citric acid.

Workup

  1. customThe following composition was prepared
  2. dissolutionto dissolve
  3. additionand the solution was filled into a syringe

Sources & evidence

ORD record
ord-022caf25e136418bbb516df466b19be9
Source dataset
uspto-grants-2012_05
Patent number
US08173148B2

Reaction notes

Loading…