Diethylamine → HCID 59305817, compound

HRID 1921682Notes

Reaction equation

HRID 1921682 reaction equation
C1C2C(COC(=O)[NH:17][CH:18]3[CH2:23][CH2:22][CH:21]([C:24]4[N:25]=[C:26]([CH3:29])[S:27][CH:28]=4)[CH2:20][CH2:19]3)C3C(=CC=CC=3)C=2C=CC=1.C(NCC)C>C1COCC1>[CH3:29][C:26]1[S:27][CH:28]=[C:24]([CH:21]2[CH2:22][CH2:23][CH:18]([NH2:17])[CH2:19][CH2:20]2)[N:25]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86643647HCID 86643647, compound

Product 1

HCID 59305817HCID 59305817, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.10 g (2 mmol) of 9H-fluoren-9-ylmethyl[4-(2-methylthiazol-4-yl)cyclohexyl]carbamate (cis compound) and 15 mL of diethylamine are stirred in 30 mL of THF for 16 hours at ambient temperature. Then the reaction mixture is concentrated by evaporation and the residue is combined with THF and concentrated again by evaporation. The residue is purified by chromatography. Yield: 0.13 g (36%).

Workup

  1. concentrationThen the reaction mixture is concentrated by evaporation
  2. concentrationconcentrated again by evaporation
  3. customThe residue is purified by chromatography

Sources & evidence

ORD record
ord-a72f4a5dfb1b49efac082325a7284bc8
Source dataset
uspto-grants-2012_05
Patent number
US08173699B2

Reaction notes

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