反应详情

温度

100 °C

A solution of 4.5 g (6.93 mmol) of ethyl 5-{[2-(5-fluoro-2-{[4′-(trifluoromethyl)biphenyl-4-yl]-methoxy}phenyl)ethyl]amino}pentanoate in 90 ml of THF is mixed with 18 ml of half-concentrated hydrochloric acid and heated at 100° C. for 20 min. After cooling, the mixture is added to water and neutralized with saturated sodium bicarbonate solution. It is extracted with ethyl acetate, the organic phase is dried over sodium sulfate and the solvent is removed in vacuo. The residue is crystallized from ethyl acetate/diethyl ether (1:1). The resulting crystals are filtered off with suction and dried under high vacuum. 2.4 g (4.9 mmol, 71% of theory) of the title compound are obtained.

1. temperatureAfter cooling
2. extractionIt is extracted with ethyl acetate
3. dry with materialthe organic phase is dried over sodium sulfate
4. customthe solvent is removed in vacuo
5. customThe residue is crystallized from ethyl acetate/diethyl ether (1:1)
6. filtrationThe resulting crystals are filtered off with suction
7. customdried under high vacuum