Ammonium Hydroxide → HCID 49783336, compound

HRID 1923502Notes

Reaction equation

HRID 1923502 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([CH2:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[S:5][C:6]=1[C:7](O)=[O:8].C(N1C=CN=C1)([N:26]1C=CN=C1)=O.[OH-].[NH4+]>CN(C=O)C>[CH3:1][C:2]1[N:3]=[C:4]([CH2:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[S:5][C:6]=1[C:7]([NH2:26])=[O:8]

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 682631,1'-CarbonyldiimidazoleHCID 66643567HCID 66643567, compound

Product 1

HCID 49783336HCID 49783336, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 4-methyl-2-[2-(5-methyl-3-pyridin-2-yl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (100 mg, 0.3 mmol) in DMF (3 mL) was added 1,1′-carbonyldiimidazole (60 mg, 0.36 mmol). The resulting reaction mixture was stirred for 1 h at 60° C. and then treated with an ammonium hydroxide solution (455 μL, 3.0 mmol) and stirred for 2 h at room temperature. The reaction mixture was then evaporated. Purification by chromatography (silica, heptane:ethyl acetate 8:2 to 1:1) afforded the title compound (79 mg, 79%) as an off white solid. MS: m/e=329.1 [M+H]+.

Workup

  1. customThe resulting reaction mixture
  2. stirringstirred for 2 h at room temperature
  3. customThe reaction mixture was then evaporated
  4. customPurification by chromatography (silica, heptane:ethyl acetate 8:2 to 1:1)

Sources & evidence

ORD record
ord-97455390428149a7ac1cc4bd987f49d3
Source dataset
uspto-grants-2012_05
Patent number
US08178522B2

Reaction notes

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