反应详情

1.54 g thieno(3,4-c)furan-1,3-dione was dissolved in 20 mL of anhydrous THF, and 12.8 g of 3-aminopiperidine-2,6-dione was added. The reaction mixture was allowed to react at room temperature for 4 h. Then, 2 g of CDI and a catalytic quantity of DMAP were added, and the reaction mixture was allowed to reflux for 6 h until a large amount of white solid precipitated. The solid was cooled and filtered to yield 2.1 g of the title product.

1. customto react at room temperature for 4 h
2. temperatureto reflux for 6 h until a large amount of white solid
3. customprecipitated
4. temperatureThe solid was cooled
5. filtrationfiltered