反应详情

To a mixture of 4-benzyloxyphenylacetyl chloride (1.1 g) and THF (10 mL) were added triethylamine (1.8 mL) and hydrazine hydrate (0.20 mL) at room temperature, which was stirred at the same temperature for 7.5 hours. Water was added to the reaction solution, which was then extracted with ethyl acetate, and the organic layer was washed with saturated brine. The solvent was evaporated under a reduced pressure, after which the residue was purified by silica gel chromatography (methanol:ethyl acetate=1:30) to obtain the titled compound (0.23 g).

1. extractionwas then extracted with ethyl acetate
2. washthe organic layer was washed with saturated brine
3. customThe solvent was evaporated under a reduced pressure
4. customafter which the residue was purified by silica gel chromatography (methanol:ethyl acetate=1:30)