HCID 68674706, compound → HCID 59443511, compound

HRID 1927675Notes

Reaction equation

HRID 1927675 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]=[C:12]([CH2:14][CH2:15][C:16]3[N:17](S(N(C)C)(=O)=O)[CH:18]=[C:19]([CH2:21][C:22]([CH3:26])([CH3:25])[CH2:23][CH3:24])[N:20]=3)[N:11]([CH3:33])[N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]>C1COCC1.Cl>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]=[C:12]([CH2:14][CH2:15][C:16]3[NH:20][C:19]([CH2:21][C:22]([CH3:26])([CH3:25])[CH2:23][CH3:24])=[CH:18][N:17]=3)[N:11]([CH3:33])[N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 1

HCID 68674706HCID 68674706, compound

Product 1

HCID 59443511HCID 59443511, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-{2-[3-(3,4-difluorophenyl)-1-methyl-1H-1,2,4-triazol-5-yl]ethyl}-4-(2,2-dimethylbutyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide (90 mg, 0.19 mmol) in THF (4 mL) and 2 M HCl (4 mL) was heated at 80° C. overnight. The volatiles were removed and the residue was washed with ethyl acetate, basified with 1 N aqueous sodium hydroxide and extracted with ethyl acetate. The combined phases were dried over sodium sulfate and concentrated to afford the title compound. LC-MS: m/e (374M+H).

Workup

  1. customThe volatiles were removed
  2. washthe residue was washed with ethyl acetate
  3. extractionextracted with ethyl acetate
  4. dry with materialThe combined phases were dried over sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-d98c8b25402e4dd6a3766a392a22e6cf
Source dataset
uspto-grants-2012_05
Patent number
US08183275B2

Reaction notes

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