Hydrochloric Acid → HCID 59483382, compound

HRID 1927810Notes

Reaction equation

HRID 1927810 reaction equation
[CH3:1][C:2]1[N:6]([CH3:7])[C:5](=[O:8])[N:4]([CH2:9][C:10]([O:12]C)=[O:11])[N:3]=1.[OH-].[Li+].Cl>O1CCCC1.O>[CH3:1][C:2]1[N:6]([CH3:7])[C:5](=[O:8])[N:4]([CH2:9][C:10]([OH:12])=[O:11])[N:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86645296HCID 86645296, compound

Product 1

HCID 59483382HCID 59483382, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

593 mg of methyl (3,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetate (Va-6) are dissolved in 5 ml of tetrahydrofuran, and 134 mg of lithium hydroxide in 2 ml of water are added. The mixture is stirred at room temperature for 16 hours, acidified with 1N hydrochloric acid and extracted with ethyl acetate. The organic phase is dried over sodium sulphate and the solvent is removed under reduced pressure. This gives 167 mg of (3,4-dimethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetic acid.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase is dried over sodium sulphate
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-3d2954e237014f14a5ec66f6f19623e2
Source dataset
uspto-grants-2012_05
Patent number
US08183351B2

Reaction notes

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