N,N-Dimethylethylenediamine → 1-(2-Dimethylamino-ethyl)-3-[2-((R)-indan-1-ylamino)-quinolin-6-yl]-urea

HRID 1928721Notes

Reaction equation

HRID 1928721 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[CH3:13][N:14]([CH3:18])[CH2:15][CH2:16][NH2:17].[C@H:19]1([NH:28][C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][CH:33]=[C:34]([NH2:39])[CH:35]=3)[N:30]=2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1>>[CH3:13][N:14]([CH3:18])[CH2:15][CH2:16][NH:17][C:1]([NH:39][C:34]1[CH:35]=[C:36]2[C:31](=[CH:32][CH:33]=1)[N:30]=[C:29]([NH:28][C@H:19]1[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21][CH2:20]1)[CH:38]=[CH:37]2)=[O:12]

Participants

4

Reactant 3

HCID 66053N,N-DimethylethylenediamineHCID 94429TriphosgeneHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 442174711-(2-Dimethylamino-ethyl)-3-[2-((R)-indan-1-ylamino)-quinolin-6-yl]-urea

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 2-dimethylamino-ethylamine and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=390.5 (M+H+).

Sources & evidence

ORD record
ord-00745c5e26c140caa91af5bd183a7409
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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