Triphosgene → 1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-(tetrahydro-pyran-4-yl)-urea

HRID 1928722Notes

Reaction equation

HRID 1928722 reaction equation
[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH2:13][CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.[C@H:20]1([NH:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[C:35]([NH2:40])[CH:36]=3)[N:31]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21]1>>[C@H:20]1([NH:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[C:35]([NH:40][C:1]([NH:13][CH:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)=[O:12])[CH:36]=3)[N:31]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 4192234-AminotetrahydropyranHCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

Product 1

HCID 442174701-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-(tetrahydro-pyran-4-yl)-urea

Procedure

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 4-aminotetrahydropyran and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=403.5 (M+H+).

Sources & evidence

ORD record
ord-eeed91b3f1e94eb68d899d322af62e75
Source dataset
uspto-grants-2012_05
Patent number
US08183380B2

Reaction notes

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