反应详情

4-Benzyloxy-1H-indole-2-carboxylic acid ethyl ester (10 g, 34 mmol) and DMAP (80 mg) are dissolved in 80 ml of ethyl acetate. BOC2O (8.9 g, 41 mmol) dissolved in a small amount of ethyl acetate is added at room temperature. The mixture is stirred over night at room temperature. Then the reaction mixture is washed with 1 m aqueous tartaric acid, water and brine. The organic layers are dried over sodium sulfate and evaporated. The crude product is used in the next step without further purification

1. additionis added at room temperature
2. washThen the reaction mixture is washed with 1 m aqueous tartaric acid, water and brine
3. dry with materialThe organic layers are dried over sodium sulfate
4. customevaporated
5. customThe crude product is used in the next step without further purification