Trifluoroacetic acid → HCID 67389700, compound

HRID 1929400Notes

Reaction equation

HRID 1929400 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH:18][C:19]([C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH2:32][CH2:31][N:30](C(OC(C)(C)C)=O)[CH2:29][CH2:28]4)=[CH:23][CH:22]=3)=[O:20])(=[O:17])=[O:16])=[CH:11][C:10]=2[N+:40]([O-:42])=[O:41])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46]>ClCCl.C([SiH](CC)CC)C>[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46].[CH:1]1([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH:18][C:19](=[O:20])[C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]4)=[CH:23][CH:22]=3)(=[O:17])=[O:16])=[CH:11][C:10]=2[N+:40]([O-:42])=[O:41])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57474951HCID 57474951, compound

Product 1

HCID 67389700HCID 67389700, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 12052TriethylsilaneSolvent

Procedure

A solution of EXAMPLE 22C (0.85 g, 1.4 mmol) in dichloromethane (10 mL), trifluoroacetic acid (10 mL) and triethylsilane (1 mL) was stirred for 24 hours. The mixture was concentrated to afford the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-a970b5c3603b436bbb234b4c1935c257
Source dataset
uspto-grants-2012_05
Patent number
US08188077B2

Reaction notes

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