Water → HCID 68915115, compound

HRID 1931360Notes

Reaction equation

HRID 1931360 reaction equation
Cl.[CH:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH:3]1[NH2:12])[CH2:9]2.[C:13](N1C=CN=C1)([N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1)=[O:14].C(N(CC)CC)C.O>C(Cl)Cl>[CH:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH:3]1[NH:12][C:13]([N:15]1[CH2:19][CH2:18][N:17]=[CH:16]1)=[O:14])[CH2:9]2

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 253312-Aminoadamantane hydrochlorideHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 68915115HCID 68915115, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2-adamantylamine hydrochloride 3 g (15.98 mmol), carbonyldiimidazole 2.59 g (15.98 mmol), triethylamine 2.215 ml (15.98 mmol) in CH2Cl2 100 ml was stirred overnight at room temperature. Water was added, the organic phase separated, dried and concentrated to dryness yielding the title crude product 3.69 g (94%) as white solid.

Workup

  1. customthe organic phase separated
  2. customdried
  3. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-a9084040e0514efe8d350f0bd9514525
Source dataset
uspto-grants-2012_05
Patent number
US08188288B2

Reaction notes

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