Benzene, 1-bromo-3,5-dichloro- → HCID 68518913, compound

HRID 1931865Notes

Reaction equation

HRID 1931865 reaction equation
Br[C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[CH:3]=1.[Mg].[C:11]([N:18]1[CH2:22][CH2:21][C:20](=[O:23])[CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>O1CCCC1>[Cl:9][C:4]1[CH:3]=[C:2]([C:20]2([OH:23])[CH2:21][CH2:22][N:18]([C:11]([O:13][C:14]([CH3:16])([CH3:15])[CH3:17])=[O:12])[CH2:19]2)[CH:7]=[C:6]([Cl:8])[CH:5]=1

Participants

5

Reactant 3

HCID 29766Benzene, 1-bromo-3,5-dichloro-HCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 5462224Magnesium

Product 1

HCID 68518913HCID 68518913, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Preparation according to Preparation 5: 1-bromo-3,5-dichlorobenzene (5.0 g, 22.1 mmol), dry tetrahydrofuran (100 mL), magnesium turnings (0.54 g, 24.3 mmol) and 1-N-boc-3-pyrrolidinone (3.25 g, 17.7 mmol). Yield: 2.1 g. MS m/z (rel. intensity, 70 eV) 332 (M+, 1), 232 (17), 231 (23), 230 (22), 57 (bp).

Workup

  1. customPreparation
  2. customaccording to Preparation 5

Sources & evidence

ORD record
ord-87b8202604c5419d9a4387120c94d5fa
Source dataset
uspto-grants-2012_05
Patent number
US08188301B2

Reaction notes

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