Hydrochloric Acid → HCID 11666949, compound

HRID 1932317Notes

Reaction equation

HRID 1932317 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][C:8]2[N:9]=[CH:10][CH:11]=[C:12]3[C:16]([CH3:17])=[C:15]([CH3:18])[NH:14][C:13]=23)=[CH:4][CH:3]=1.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][C:8]2[N:9]=[CH:10][CH:11]=[C:12]3[C:16]([CH3:17])=[C:15]([CH3:18])[NH:14][C:13]=23)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11572801HCID 11572801, compound

Product 1

HCID 11666949HCID 11666949, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 7-(4-chlorophenoxymethyl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine prepared in Example 41 in ethyl acetate (10 ml) was saturated with hydrochloric acid gas and then filtered. The resulting solid was dried under reduced pressure to give the titled compound as a white solid. (Yield: 90%)

Workup

  1. filtrationfiltered
  2. customThe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-712b43200186494ca7a291d4297e46b2
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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