Hydrochloric Acid → HCID 67142110, compound

HRID 1932384Notes

Reaction equation

HRID 1932384 reaction equation
[CH2:1]([N:4]1[C:8]2=[C:9]([N:24]3[CH2:33][CH2:32][C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:25]3)[N:10]=[C:11]([C:13]([NH:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)=[O:14])[CH:12]=[C:7]2[C:6]([CH3:34])=[C:5]1[CH3:35])[CH:2]=[CH2:3].[ClH:36]>C(OCC)(=O)C>[ClH:36].[CH2:1]([N:4]1[C:8]2=[C:9]([N:24]3[CH2:33][CH2:32][C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:25]3)[N:10]=[C:11]([C:13]([NH:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)=[O:14])[CH:12]=[C:7]2[C:6]([CH3:34])=[C:5]1[CH3:35])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67142111HCID 67142111, compound

Product 1

HCID 67142110HCID 67142110, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 1-allyl-7-(3,4-dihydro-1H-isoquinolin-2-yl)-2,3-dimethyl-N-(4-methylbenzyl)-1H-pyrrolo[2,3-c]pyridin-5-carboxamide prepared in Step 1 in ethyl acetate was saturated with hydrochloric acid gas and then filtered to give the titled compound as a white solid. (Yield: 90%)

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-1a5ba6a5a71e43c59d4826532be03044
Source dataset
uspto-grants-2012_05
Patent number
US08188114B2

Reaction notes

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