Dimethylformamide → 2-(2-cyclohexylethyl)-4-morpholin-4-yl-4-oxo-N-[1-[4-(trifluoromethoxy)anilino]propan-2-yl]butanamide

HRID 193411Notes

Reaction equation

HRID 193411 reaction equation
[CH3:76][CH2:77][O:78][C:79](=[O:80])[CH3:81].[CH:1]1([CH2:7][CH2:8][CH:9]([C:10](=[O:11])[OH:12])[CH2:13][C:14](=[O:15])[N:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[CH:62]([N:63]([CH2:64][CH3:65])[CH:66]([CH3:67])[CH3:68])([CH3:69])[CH3:70].[Cl:82][CH2:83][Cl:84].[F:46][C:47]([O:48][c:49]1[cH:50][cH:51][c:52]([NH:55][CH2:56][CH:57]([CH3:58])[NH2:59])[cH:53][cH:54]1)([F:60])[F:61].[O:71]=[CH:72][N:73]([CH3:74])[CH3:75].[P-:22]([F:23])([F:24])([F:25])([F:26])([F:27])[F:28].[n:29]1([O:30][C:31]([N:32]([CH3:33])[CH3:34])=[N+:35]([CH3:36])[CH3:37])[c:38]2[n:39][cH:40][cH:41][cH:42][c:43]2[n:44][n:45]1>>[CH:1]1([CH2:7][CH2:8][CH:9]([C:10](=[O:12])[NH:59][CH:57]([CH2:56][NH:55][c:52]2[cH:51][cH:50][c:49]([O:48][C:47]([F:46])([F:60])[F:61])[cH:54][cH:53]2)[CH3:58])[CH2:13][C:14](=[O:15])[N:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

9

Reactant 8

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 21082274N1-[4-(trifluoromethoxy)phenyl]propane-1,2-diamineHCID 220539862-(2-Cyclohexylethyl)-4-morpholin-4-yl-4-oxobutanoic acid

Product 1

HCID 684799222-(2-cyclohexylethyl)-4-morpholin-4-yl-4-oxo-N-[1-[4-(trifluoromethoxy)anilino]propan-2-yl]butanamide

Sources & evidence

ORD record
ord-fe63fdffb6ef4a59b67f1a17afc35715
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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