1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 22467018, compound

HRID 1934574Notes

Reaction equation

HRID 1934574 reaction equation
N12CCCN=C1CCCCC2.C(O[CH2:16][C@H:17]1[C@H:20]([CH2:21][O:22][C:23](=[O:25])[CH3:24])[CH2:19][C:18]1=[O:26])(=O)C>O1CCCC1>[C:23]([O:22][CH2:21][CH:20]1[CH2:19][C:18](=[O:26])[C:17]1=[CH2:16])(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 69921356HCID 69921356, compound

Product 1

HCID 22467018HCID 22467018, compoundYield 106.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

After tetrahydrofuran (3 ml) and 1,8-diazabicyclo[5.4.0]-undeca-7-ene (25.5 mg, 0.168 mmol) was added to Compound (c) (30 mg, 0.14 mmol), the mixture was stirred at room temperature for an hour. The reaction solution was purified by silica gel column chromatography (10 ml, hexane:ethyl acetate=2:1) to give Compound (d) (23 mg, yield: 95.5%).

Workup

  1. customThe reaction solution was purified by silica gel column chromatography (10 ml, hexane:ethyl acetate=2:1)

Sources & evidence

ORD record
ord-ded565881d84405f8dee27026db2f449
Source dataset
uspto-grants-2002_05
Patent number
US06384063B1

Reaction notes

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