Hydrochloric Acid → HCID 10129999, compound

HRID 1935729Notes

Reaction equation

HRID 1935729 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.Cl.[CH3:8][NH:9][CH3:10].Cl.C=O.[OH-].[K+].[C:16](=O)([O-])[O-].[K+].[K+]>O>[CH3:8][N:9]([CH2:16][N:3]1[CH:4]=[CH:5][N:6]=[C:2]1[CH3:1])[CH3:10]

Participants

8

Reactant 6

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 11430Potassium CarbonateHCID 127492-MethylimidazoleHCID 14797Potassium Hydroxide

Product 1

HCID 10129999HCID 10129999, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

20 g of 2-methylimidazole and 20 g of dimethylamine hydrochloride were dissolved in 50 ml of distilled water, and pH of the solution was adjusted to 5 with conc. hydrochloric acid. 22 g of 37% aqueous formaldehyde was added to the solution and kept at room temperature for 24 hrs. Then, the resulting solution was alkalized with 20% potassium hydroxide, saturated with potassium carbonate and extracted with chloroform. The organic layer was dried over potassium carbonate, and then vacuum-distilled, to obtain 28.1 g of the title compound (yield: 83%).

Workup

  1. extractionextracted with chloroform
  2. dry with materialThe organic layer was dried over potassium carbonate
  3. distillationvacuum-distilled

Sources & evidence

ORD record
ord-f9038e7fa1dc4c59b8b1e37993e8db92
Source dataset
uspto-grants-2002_05
Patent number
US06388091B1

Reaction notes

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