Dichloromethane → 17-Ethyl-1-hydroxy-14-(tert-butyldimethylsiloxy)-12-[2'-(4"-(tert-butyldimethylsiloxy)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone

HRID 193580Notes

Reaction equation

HRID 193580 reaction equation
[CH2:1]([CH3:2])[CH:3]1[C:4](=[O:65])[CH2:5][CH:6]([OH:64])[CH:7]([CH3:63])[CH:8]([C:42](=[CH:43][CH:44]2[CH2:45][CH:46]([O:58][CH2:59][CH:60]=[CH2:61])[CH:47]([O:50][Si:51]([CH3:52])([CH3:53])[C:54]([CH3:55])([CH3:56])[CH3:57])[CH2:48][CH2:49]2)[CH3:62])[O:9][C:10](=[O:41])[CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[C:17](=[O:40])[C:18](=[O:39])[C:19]2([OH:38])[CH:20]([CH3:37])[CH2:21][CH:22]([O:35][CH3:36])[CH:23]([CH:24]([O:32][CH3:33])[CH2:25][CH:26]([CH3:31])[CH2:27][C:28]([CH3:30])=[CH:29]1)[O:34]2.[CH2:89]([Cl:90])[Cl:91].[CH3:92][CH2:93][O:94][C:95](=[O:96])[CH3:97].[F:74][C:75]([F:76])([F:77])[S:78]([O:79][Si:80]([CH3:81])([CH3:82])[C:83]([CH3:84])([CH3:85])[CH3:86])(=[O:87])=[O:88].[n:66]1[c:67]([CH3:68])[cH:69][cH:70][cH:71][c:72]1[CH3:73]>>[CH2:1]([CH3:2])[CH:3]1[C:4](=[O:65])[CH2:5][CH:6]([O:64][Si:80]([CH3:81])([CH3:82])[C:83]([CH3:84])([CH3:85])[CH3:86])[CH:7]([CH3:63])[CH:8]([C:42](=[CH:43][CH:44]2[CH2:45][CH:46]([O:58][CH2:59][CH:60]=[CH2:61])[CH:47]([O:50][Si:51]([CH3:52])([CH3:53])[C:54]([CH3:55])([CH3:56])[CH3:57])[CH2:48][CH2:49]2)[CH3:62])[O:9][C:10](=[O:41])[CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[C:17](=[O:40])[C:18](=[O:39])[C:19]2([OH:38])[CH:20]([CH3:37])[CH2:21][CH:22]([O:35][CH3:36])[CH:23]([CH:24]([O:32][CH3:33])[CH2:25][CH:26]([CH3:31])[CH2:27][C:28]([CH3:30])=[CH:29]1)[O:34]2

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 79372,6-LutidineHCID 8857Ethyl AcetateHCID 123564tert-Butyldimethylsilyl trifluoromethanesulphonateHCID 5713502317-Ethyl-1,14-dihydroxy-12-[2'-(4"-(tert-butyldimethylsiloxy)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone

Product 1

HCID 13171763617-Ethyl-1-hydroxy-14-(tert-butyldimethylsiloxy)-12-[2'-(4"-(tert-butyldimethylsiloxy)-3"-allyloxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone

Sources & evidence

ORD record
ord-90d9cfc80cbf4929ac499c80da049182
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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