Triphosgene → HCID 22462532, compound

HRID 1936719Notes

Reaction equation

HRID 1936719 reaction equation
[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:3]=1[NH2:4].[NH2:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[C:20]2[CH:26]1[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]1.Cl[C:34](Cl)([O:36]C(=O)OC(Cl)(Cl)Cl)Cl>C(N(CC)CC)C>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:3]=1[NH:4][C:34]([NH:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[C:20]2[CH:26]1[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]1)=[O:36]

Participants

5

Reactant 3

HCID 94429TriphosgeneHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amineHCID 22462535HCID 22462535, compound

Product 1

HCID 22462532HCID 22462532, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared in a similar manner to Example 1 from 2,3-dichloro-4-(pyridin-4-yl)aniline (D9, 0.20 g, 0.85 mmole), 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole (D2, 0.15 g, 0.66 mmole), triphosgene (0.10 g, 0.34 mmole) and triethylamine (0.30 ml). This was obtained as a pink white solid (0.18 g).

Sources & evidence

ORD record
ord-260532b857ee40769c3848ba1950a93e
Source dataset
uspto-grants-2002_05
Patent number
US06391891B1

Reaction notes

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