反应详情

858 mg of ethyl N-methyl-4-aminobutyrate hydrochloride, 238 mg of triethylamine, 4 ml of 2-propanol and 2 ml of N,N-dimethylformamide were added to 400 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was refluxed for 1 hour, cooled to room temperature and filtered. The filtrate was distilled under a reduced pressure to remove the solvent and the residue was recrystallized (from ethanol/water) to give 410 mg of the title compound.

1. temperatureThe obtained mixture was refluxed for 1 hour
2. filtrationfiltered
3. distillationThe filtrate was distilled under a reduced pressure
4. customto remove the solvent
5. customthe residue was recrystallized (from ethanol/water)