反应详情

To a mixture of N,S-dimethyl-N'-nitroisothiourea (500 mg), potassium carbonate (695 mg) and acetonitrile (10 ml) was added 376 mg of acetic anhydride at room temperature. After stirring at room temperature for 5 hours, 10 ml of 2N hydrochloric acid was added to the mixture which was then extracted with 40 ml of dichloromethane. The resultant organic layers were washed with aqueous saturated sodium bicarbonate, then dried over anhydrous magnesium sulfate and concentrated to afford 600 mg of N-acetyl-N,S-dimethyl-N'-nitroisothiourea as a white crystal, mp 40°-41° C.

1. extractionwas then extracted with 40 ml of dichloromethane
2. washThe resultant organic layers were washed with aqueous saturated sodium bicarbonate
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated