Water → HCID 19367598, compound

HRID 1939637Notes

Reaction equation

HRID 1939637 reaction equation
[F-:1].[K+].C1OCCOCCOCCOCCOCCOC1.Cl[C:22]1[N:31]2[CH:32]=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[F:41])[N:34]=[C:30]2[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1.O>CN(C=O)C>[F:1][C:22]1[N:31]2[CH:32]=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[F:41])[N:34]=[C:30]2[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2855718-Crown-6HCID 522689Potassium FluorideHCID 15284102HCID 15284102, compound

Product 1

HCID 19367598HCID 19367598, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 700 mg of potassium fluoride and 200 mg 18-crown-6 in 10 mL of DMF was added 5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (200 mg). This mixture was refluxed for 1.5 h, cooled to room temperature and poured into water. The aqueous solution was extracted with ethyl acetate, the organic layer was separated and dried, and the solvent removed in vacuo to yield 5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 41), m.p. 154°-155° C.

Workup

  1. temperatureThis mixture was refluxed for 1.5 h
  2. extractionThe aqueous solution was extracted with ethyl acetate
  3. customthe organic layer was separated
  4. customdried
  5. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-ffa7ff7336404297bba76d6b7ae6d46e
Source dataset
uspto-grants-1997_12
Patent number
US05696260

Reaction notes

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