Acetyl chloride → 5-Acetoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline

HRID 1939641Notes

Reaction equation

HRID 1939641 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[C:10]2[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[NH:13][C:12](=[O:20])[N:11]2[CH:21]=1.[H-].[Na+].[C:24](Cl)(=[O:26])[CH3:25]>CN(C=O)C.C(OCC)(=O)C>[C:24]([N:13]1[C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]=2[C:10]2=[N:9][C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])=[CH:21][N:11]2[C:12]1=[O:20])(=[O:26])[CH3:25].[C:24]([O:20][C:12]1[N:11]2[CH:21]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[N:9]=[C:10]2[C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[N:13]=1)(=[O:26])[CH3:25]

Participants

7

Reactant 3

HCID 6367Acetyl chlorideHCID 24758Sodium hydrideHCID 152840972-(2-Fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one

Product 2

HCID 193675705-Acetoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolineHCID 19367582HCID 19367582, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 2-(2-Fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (283 mg) and 50% sodium hydride (144 mg) in DMF (5 mL) was stirred at room temperature for 15 min. Acetyl chloride (1 mL) was added and stirring was continued for 30 min. The reaction was diluted with ethyl acetate and washed with water. After drying over magnesium sulfate, the solvent was removed in vacuo and the residue was subjected to flash chromatography on silica gel with 30% ethyl acetate in hexane as the eluent to afford 6-Acetyl-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (Compound 47) and 5-Acetoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 48) as white solids.

Workup

  1. stirringstirring
  2. waitwas continued for 30 min
  3. washwashed with water
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-17b487cfa53842c6aeb5c1de8fa3cca1
Source dataset
uspto-grants-1997_12
Patent number
US05696260

Reaction notes

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