反应详情

温度

45 °C

Heat [(CH3)3Si]2NLi (230 ml, 1.0M in THF) under N2 to 45° C. and add 3,4 dichlorophenyl acetic acid methyl ester (40 g, 0.183 moles) dissolved in 60 ml of dry THF dropwise over 2 h. Stir the solution at 45° C. for another 2.5 h. Cool the solution to room temperature, add a dry THF solution (30 ml.) of THP-protected Br(CH2)2OH dropwise over 1 h., and stir the solution for 24 h. Cool the solution in an ice bath and quench the reaction by adding, dropwise, 250 ml. of 1.0M aqueous HCl. Extract the solution with Et2 O, wash the organic layer twice with 1.0M aqueous HCl, then with water, and dry over anhydrous Na2SO4. Remove the solvent, dissolve the residue in CH3OH and add 0.5 g of pTSA. Stir the solution at room temperature overnight, remove the solvent, add CH3OH (500 ml) and stir for 6 h. Remove the solvent again, add more CH3OH (500 ml.), stir overnight and remove the solvent. Dissolve the resulting oil in CH2Cl2 (1200 ml.), wash twice with saturated aqueous NaHCO3, then water, and dry over anhydrous Na2SO4. Remove the solvent in vacuo. Purify the reaction mixture by flash chromatography (SiO2) using EtOAc: hexanes (3:7) as eluent. Yield: 22 g. Cl-MS: 231 (100%), 233 (65%).

1. temperatureCool the solution to room temperature
2. stirringstir the solution for 24 h
3. temperatureCool the solution in an ice bath
4. customquench
5. customthe reaction
6. additionby adding
7. extractionExtract the solution with Et2 O
8. washwash the organic layer twice with 1.0M aqueous HCl
9. dry with materialwith water, and dry over anhydrous Na2SO4
10. customRemove the solvent
11. dissolutiondissolve the residue in CH3OH
12. additionadd 0.5 g of pTSA
13. stirringStir the solution at room temperature overnight
14. customremove the solvent
15. additionadd CH3OH (500 ml)
16. stirringstir for 6 h
17. customRemove the solvent again
18. additionadd more CH3OH (500 ml.)
19. stirringstir overnight
20. customremove the solvent
21. dissolutionDissolve the resulting oil in CH2Cl2 (1200 ml.)
22. washwash twice with saturated aqueous NaHCO3
23. dry with materialwater, and dry over anhydrous Na2SO4
24. customRemove the solvent in vacuo
25. customPurify the reaction mixture by flash chromatography (SiO2)