反应详情

An aqueous solution (25 ml) containing 4.30 g of anhydrous potassium carbonate was added to a suspension in which 2.01 g of 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide was suspended in ethyl acetate (40 ml) and tetrahydrofuran (10 ml). Under ice cooling, 2.23 g of nicotinic acid chloride hydrochloride was added thereto, and the mixture was stirred for 3 hours. Precipitated crystal was collected by filtration, washed with water, dried and then recrystallized from methanol to obtain 1.30 g of 6-[4-(4-(pyridin-3-ylcarbonylamino)butyl)phenyl]pyridazin-3(2H)-one.

1. customPrecipitated crystal
2. filtrationwas collected by filtration
3. washwashed with water
4. customdried
5. customrecrystallized from methanol