1-Bromo-3-chloropropane → HCID 11858012, compound

HRID 1939951Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].Br[CH2:11][CH2:12][CH2:13]Cl.[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>>[CH2:15]([N:17]([CH2:18][CH3:19])[CH2:11][CH2:12][CH2:13][O:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)[CH3:16]

Participants

Reactant 3

HCID 80061-Bromo-3-chloropropane

HCID 8021Diethylamine

HCID 130194-Cyanophenol

Product 1

HCID 11858012HCID 11858012, compoundYield 100%

Procedure

According to a similar manner as that in Reference Example 36 except that 4-cyanophenol, 1-bromo-3-chloropropane, and diethylamine were used, 4-[3-(diethylamino)propoxy]benzonitrile (100%) was obtained as a crude product.

Sources & evidence

ORD record: ord-7bb4661eade747ffaccf189807f7fa14
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698560

Reaction notes

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