1-Bromo-3-chloropropane → 4-[3-(4-Morpholinyl)propoxy]benzonitrile

HRID 1939955Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].Br[CH2:11][CH2:12][CH2:13]Cl.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[O:18]1[CH2:19][CH2:20][N:15]([CH2:11][CH2:12][CH2:13][O:9][C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:16][CH2:17]1

Participants

Reactant 3

HCID 80061-Bromo-3-chloropropane

HCID 8083Morpholine

HCID 130194-Cyanophenol

Product 1

HCID 29938364-[3-(4-Morpholinyl)propoxy]benzonitrile

Procedure

According to a similar manner as that in Reference Example 78 except that 4-cyanophenol, 1-bromo-3-chloropropane, and morpholine were used, 4-(3-morpholinopropoxy)benzonitrile (quantitative) was obtained as a crude product.

Sources & evidence

ORD record: ord-03fc735140404d9084a0497c44ab91f8
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698560

Reaction notes

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