Trifluoroacetic acid → HCID 67624327, compound

HRID 1940390Notes

Reaction equation

HRID 1940390 reaction equation
C([C:5](C(C)(C)C)([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([OH:37])[CH2:17][NH:18][C:19]([C:21]2[S:22][C:23]3[CH2:24][NH:25][CH:26](C(OC(C)(C)C)=O)[CH2:27][C:28]=3[N:29]=2)=[O:20])=[CH:12][C:11]=1[O:38][CH2:39][C:40]([O-:42])=[O:41])[C:6]([O-:8])=[O:7])(C)(C)C.[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].C(OC(C)C)(C)C>C1(OC)C=CC=CC=1>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[N:29]1[C:28]2[CH2:27][CH2:26][NH:25][CH2:24][C:23]=2[S:22][C:21]=1[C:19]([NH:18][CH2:17][CH:16]([C:13]1[CH:14]=[CH:15][C:10]([O:9][CH2:5][C:6]([OH:8])=[O:7])=[C:11]([O:38][CH2:39][C:40]([OH:42])=[O:41])[CH:12]=1)[OH:37])=[O:20]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7914Diisopropyl EtherHCID 86751748HCID 86751748, compound

Product 1

HCID 67624327HCID 67624327, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

To the solution of the compound prepared in (a) (115.3 mg, 0.174 mmole) in anisole (0.5 ml) was added trifluoroacetic acid (2.0 ml) at 0° C. Crystals were deposited by the addition of isopropyl ether at 0° C., collected by filtration, and lyophilized to give 82.1 mg of a crude product, which was purified on a LH column (50% methanol) to give 76.6 mg of the title compound as a colorless crystal (yield, 77.8%).

Workup

  1. filtrationcollected by filtration
  2. customto give 82.1 mg of a crude product, which
  3. customwas purified on a LH column (50% methanol)

Sources & evidence

ORD record
ord-e6e55958d38d417fbbfa74a6163c5a77
Source dataset
uspto-grants-1997_12
Patent number
US05698692

Reaction notes

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