Trifluoroacetic acid → HCID 178484467, compound

HRID 1940395Notes

Reaction equation

HRID 1940395 reaction equation
C([C:5](C(C)(C)C)([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:31])[CH2:17][N:18]([C:20]([C@H:22]2[CH2:27][CH2:26][C@H:25]([C:28](=[NH:30])[NH2:29])[CH2:24][CH2:23]2)=[O:21])[CH3:19])=[CH:12][C:11]=1[O:32][CH2:33][C:34]([O-:36])=[O:35])[C:6]([O-:8])=[O:7])(C)(C)C.[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].C(OC(C)C)(C)C>C1(OC)C=CC=CC=1>[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].[C:28]([C@H:25]1[CH2:26][CH2:27][C@H:22]([C:20]([N:18]([CH2:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([O:9][CH2:5][C:6]([OH:8])=[O:7])=[C:11]([O:32][CH2:33][C:34]([OH:36])=[O:35])[CH:12]=2)=[O:31])[CH3:19])=[O:21])[CH2:23][CH2:24]1)(=[NH:29])[NH2:30]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7914Diisopropyl EtherHCID 178484464HCID 178484464, compound

Product 1

HCID 178484467HCID 178484467, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

To the solution of the compound prepared in (d) (50 mg, 0.089 mmole) in anisole was added trifluoroacetic acid under ice-cooling. The mixture was stirred for 5 hours, during which the temperature of the mixture was left rising up to room temperature. After isopropyl ether was added to the reaction mixture, solids deposited were collected to give 31 mg of the title compound as the colorless solid (yield, 62%).

Workup

  1. temperaturecooling
  2. waitwas left
  3. customrising up to room temperature
  4. customdeposited were collected

Sources & evidence

ORD record
ord-cba0c55117f040dbbc3c65cce3bd0376
Source dataset
uspto-grants-1997_12
Patent number
US05698692

Reaction notes

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